In conclusion, our findings suggested that GLP-1RAs induced significant reductions in the depression rating scales compared to control treatments. GLP-1RAs may be a potential treatment for alleviating depressive symptoms in humans. Further RCTs need to be performed with large samples and of high quality to verify the antidepressant activity of GLP-1RAs, and should take the follow-up time, primary diagnosis of participants, depression rating scales, the agents and dosage of GLP-1RAs, and control conditions into consideration. Moreover, it still needs to be determined whether the newly launched GLP-1RAs have antidepressant effects.


https://www.ajgponline.org/article/S1064-7481(23)00394-9/fulltext

Needs more studying, but some glp1s actually fix depression symptoms.