It's not just a favored team losing. Jacksonville State beating Eastern Michigan isn't a meaningful upset.  Neither is Hawaii beating Sam Houston St.

The game needs to involve a meaningfully favored team (probably more than a FG favorite) losing in a high-profile way.  So that's basically teams in the Top 25 or major marquee brands or teams on a major network

So here's (in game time order) the potential upsets that matter today (at least nationally, I'm sure the Sam Houston fans would be unhappy to lose). Others can supplement, but these are the ones that would headline the day

1. 4 Alabama @ Wisconsin (Alabama -16.5)
2. 13 Oklahoma St @ Tulsa (Oklahoma St -17.5)
3. 16 LSU @ South Carolina (LSU -6)
4. Arkansas St @ 17 Michigan (Mich -22)
5. Memphis @ Florida St (Florida St -6.5)
6. 24 Boston College @ 6 Mizzou (Mizzou -14.5)
7. 9 Oregon @ Oregon St (Oregon -17)
8. Ball St @ 10 Miami (Miami -36.5)
9. Tulane @ 15 Oklahoma (Oklahoma -12.5)
10. 18 Notre Dame @ Purdue (Notre Dame -7.5)
11. Washington St @ Washington (Washington -5.5)
12. 12 Utah @ Utah St (Utah -18)
13. 5 Ole Miss @ Wake Forest (Ole Miss -21)
14. UTSA @ 2 Texas (Texas -35)
15. 1 Georgia @ Kentucky (Georgia -22)
16. Northern Iowa @ 23 Nebraska (Nebraska -30.5)
17. New Mexico @ Auburn (Auburn -27)
18. Colorado @ CSU (Colorado -7.5)
19. Kent St @ 7 Tennessee (Tennessee -49)

Of those 19, 8 involve a ranked and favored team going on the road as solid, but not overwhelming favorites.  Those are probably the best bets for upsets

1. 4 Alabama @ Wisconsin (Alabama -16.5)
2. 13 Oklahoma St @ Tulsa (Okla St -17.5)
3. 16 LSU @ South Carolina (LSU -6)
4. 9 Oregon @ Oregon St (Oregon -17)
5. 18 Notre Dame @ Purdue (ND -7.5)
6. 12 Utah @ Utah St (Utah -18)
7. 5 Ole Miss @ Wake Forest (Ole Miss -21)
8. 1 Georgia @ Kentucky (Georgia -22)

Of those, I think the most likely are Oklahoma St (have been inconsistent), Oregon (have been downright mediocre) and Utah (not yet really tested and with their QB out)