KU gives them a really good game in a couple weeks as KU will be giving their season one last effort to keep themselves in the running for a bowl game. So there's potential for ISU to suffer a big upset their.
If they remain unscathed there, then their best chance at a loss is that last game vs KSU in this Farmageddon game. With KSU having faced BYU and CU on the road and grinding out a very close win in their Sunflower Showdown with rival KU this past weekend, KSU will be rolling into that ISU game being very much battle tested.