The metrics used today are great at adjusting so that if you win by 20 to a lousy team then the next week lose by 5 to a great team the two games will count equally to the benefit of your resume. They are designed to measure your teams strength regardless of who you are playing.

Of course there are limitations and weaknesses of these metrics, and different types of metrics that weigh wins differently, but they are good enough that I don’t think you could definitively say that any given team would have a greater likelihood of making the tourney if they were in one conference over another (comparing WCC to Big 12)