until B10 and SEC split off, make a few years of incredible money before realizing they've killled the cash cow and turned into the NFL-lite. the country will also get VERY tired (they already are) of Alabama, Georgia and Ohio state playing for a championship every single year. It's so boring.
Meanwhile, the rest of the country makes a new football conference that prioritizes regional football with rivalries and a playoff. Won't be long before there's demand that the champion of each league play each other. Then you have the AFC/NFC scenario that merges into a professional college football conference.