Haven't played enough to remember what the different difficulties are, but on the standard difficulty, I can play pretty even against almost any opponent, doesn't matter if it's Wyoming or Georgia. Put the difficulty down 1 level and I beat teams about 100-0. It goes from not being able to have a run generate more than 2 or 3 yards ever, to being able to run for 1st downs or touchdowns on every play. Set the difficulty up 1 level and it goes to the point that all rushing plays are negative and most passing plays result in immediate sacks