other side. Unless you are clearly better than the other team in the trenches, the gaps will be plugged very quickly. You also run the risk of penetration - which is so common.
In normal situations, yes, running out of the gun works well because the defense has to respect the pass game and it also gives time for blocking to develop (ie. traps, pulls). My issue here is 4th and short or 3rd and short. Get short yardage with speed and power. Just my preference.