The Big 12 has a mixed non-conference record against Power 4 opponents this season. Some notable results include a 20-19 win by Iowa State over Iowa, but also losses such as Kansas falling to Illinois 23-17 and West Virginia losing to Penn State 34-12. As of now, the conference's overall performance against Power 4 schools is below .500, indicating some struggles against high-level competition [oai_citation:1,Big 12 vs Other Conferences - topdan.com](https://topdan.com/college-football-conference-records/big-12.html).