RB1 - McCaffrey - OUT
RB2 - Elijah Mitchell - OUT
RB3 - Jordan Mason - OUT
RB4 - Isaac Guerendo - Maybe OUT
Fortunately, it's easy to find a functional RB because there's an abundance of them on practice squads, but that's still a long list of RBs to lose for a season.
Gurendo may still play again before the season is finished, but there's a chance he won't return.