Maybe it is no big deal. And maybe it is just unavoidable due to many variables.
One thing that has always marginally annoyed me, is the uneven days between games. For example, it seems unfair to schedule a game before Saturday between a team that played the previous Saturday and one who has had a bye. (a short week vs a bye).
I know teams have some control over their own schedules (especially OOC), but have always thought the conference should try to avoid the major disparities. You are always going to have teams playing where one had a bye and one did not.